Journal of Pharmaceutical Science and Herbal Technology

THE EFFECT OF COMBINATION MENIRAN ROOT (Phylanthus niruri L.) AND JAVA ACID LEAVES (Tamarindus indica L.) on ALOKSAN-INDUCED DARNESS GLUCOSA RATS (Rattus norvegicus)

Muhammad Asri SR — 2024-02-29

Meniran root (Phylanthus niruri L.) and tamarind (Tamarindus indica L.) have flavonoid compounds that function to repair pancreatic tissue damage caused by DNA alkyl groups from alloxan induction. This study aims to determine the activity of a combination of meniran root extract (Phylanthus niruri L.) and tamarind leaves (Tamarindus indica L.) on blood glucose levels of male rats (Rattus norvegicus) induced by alloxan. This study was carried out experimentally. White rats up to 15 heads were divided into 5 groups. Alloxan induction at a dose of 125 mg/kgBB intraperitoneally to cause pancreatic damage was performed in 5 treatment groups. Three treatment groups were treated with different doses of a combination of meniran and tamarind root extracts, (P1) 7.5 mg/KgBB, (P2) 10 mg/KgBB and (P3) 15 mg/KgBB, one group as negative control (K-) was given 1% Na CMC and positive control (K+) was given 5 mg glibenclamide. The combination of meniran root extract (Phylanthus niruri L.) and tamarind leaf (Tamarindus indica L.) was given for 1 day. Glucose levels were checked after 2 hours, 4 hours, 6 hours and 24 hours of administration. The results showed that the three concentrations of a combination of meniran root extract (Phylanthus niruri L.) and tamarind leaf (Tamarindus indica L.) can reduce the blood glucose levels of male rats (Rattus norvegicus) induced by alloxan.

FORMULATION OF ANTI-ACNE MASK OF PAPAYA LEAF EXTRACT (Carica papaya L.) AND HONEY AGAINST Propionibacterium acn

Putri Wali — 2024-02-29

Papaya leaves (Carica papaya L.) are ornamental plants that are very useful because they contain alkaloids, flavonoids, saponins, tannins and terpenoids. The alkaloids here have antibacterial properties. Honey is usually used as an antibacterial. Apart from being an antibacterial, honey is also an antioxidant because honey contains vitamin C. Acne (Acne vulgaris) is a skin disease caused by chronic inflammation with a complex pathogenesis, involving the sebaceous glands caused by the bacteria Propiobacerium acne. This research aims to determine whether the anti-acne mask formulation of papaya leaf extract and honey is physically and chemically stable and that the anti-acne mask formulation of papaya leaf extract and honey has anti-acne activity against Propionibacterium acne. This research is an experimental laboratory using the diffusion technique so that the well method is used to determine the diameter of the inhibition zone and for data analysis using the one-way ANOVA test. The results of research on the formulation of an anti-acne mask from papaya leaf extract and honey are physically and chemically stable. The anti-acne mask formulation of papaya leaf and honey extract has antibacterial activity against Propionibacterium acne with an inhibition zone of 17.2 mm (strong) in formulation 1, 19.6 mm (strong) in formulation 2, 19.8 (strong) in formulation 3 and 21.9 mm (very strong) on the positive cotrol, namely benzolac (Benzolic peroxide).

FORMULATION OF LIP TINT FROM EXTRACTS OF KEPOK BANANA FLOWER (Musa paradisiaca Linn.) AND DRAGONFRUIT (Hylocereus polyrhizus) AS NATURAL COLOURS

Agriawan Sudirman — 2024-02-29

Lip tint is a cosmetic preparation used to color lips which has liquid texture with a more natural color so that it is easily absorbed and produces a natural color like the lips’ original color. This research aimed to determine whether kepok banana flower peel extract (Musa paradisiaca Linn.) and dragon fruit (Hylocereus polyrhizus) can be formulated in the from of lip tint preparations as natural dyes and to test the antioxidant activity of lip tint preparations. The research method was experimental research by making lip tint formulations with concentrations of FI (2%), FII (6%), and FIII (10%) from banana peel and dragon fruit extracts, evaluating the preparations using physicochemical methods and testing antioxidant activity using the method DPPH using a UV-Vis spectrophotometer. The results showed that the total anthocyanin content in the peel of the kepok banana flower was 0,374 mg/L and in dragon fruit it was 8,232 mg/L. Lip tint preparation formulas with concentrations of 2%, 6% and 10% are physically and chemically stable and the antioxidant activity test in Formula I (2%) obtained an IC₅₀ value of 3,52 µg/mL, Formula II (6%) obtained an IC₅₀ value of 3,91 µg/mL, Formula III (10%) obtained an IC₅₀ value of 1,62 µg/mL and in the positive control comparison (Lip Tint Implora®) an IC₅₀ value of 1,98 µg/mL was obtained. The formula with a concentration of 10% has an IC₅₀ value of 1,62 µg/mL in the very strong category.

FORMULATION OF BRIGHTENING GEL WITH ETANOL EXTRACT OF RED PAWPAW LEAVES (Syzygium oleana) AS ANTIOXIDANT

Suryanita — 2024-02-29

Excessive sun exposure can have a negative impack on the skin. One way that can be done to reduce this impact is to use sunscreen. This research aimed to determine whether the ethanol of red shoot leaves (Syzygium oleana) can be formulated into a gel preparation that is physically and chemically stable and to determine sunscreen activity based on the SPF value using the UV-VIS spectrophotometric method. The method in this research was laboratory experimental. Red shoot leaves were extracted by using the maceration method with a preparation formula designe in three concentration, namely Formula 1 (1%), Formula 2 (3%),and Formula 3 (5%). Then a stability test was carried out by storing at temperatures of 4⁰C and 40⁰C. Evaluation of preparation qualityincludes organoleptic, homogeneity, pH, viscosity, and spreadability test. An SPF value test was also carried out. The research results that have been carried out show that the ethanol extract of red shoot leaves with concentration of 1% 3% and 5% formulated in gel form produces a stable preparation and meets the quality requirements of the preparation. The SPF value from formula 1 is 2,508349 (minimal protection), formula 2 3,380475 (minimal protection) and formula 3 2,679704 (minimal protection).

THE COMMUNITY KNOWLEDGE ON USE OF TRADITIONAL MEDICINE FOR SELF-MEDICATION IN MANGNGI HAMLET, NOSU SUB-DISTRICT

Ferna Indrayani — 2024-02-29

Traditional medicines are ingredients or ingredients in the form of plants, animals, minerals, galenic preparations or mixtures of various ingredients that have been used for generations as medicine and can be used by the community in accordance with applicable norms. Self-medication or self-medication is an attempt by the community to treat complaints or symptoms of illness on their own without the help of medical personnel. This study aims to determine the description of public knowledge about the use of traditional medicine as self-medication in Mangngi' Hamlet, Nosu District. The type of research used is descriptive research. The research was conducted on June 20-22 2023 for respondents who live in Dusun Mangngi' with the number of respondents using a questionnaire. The description of the use of traditional medicine as self-medication in Dusun Mangngi' is that people who know well (94.74%) and less (5.26%).

THE FORMULATION OF CREAM PREPARATIONS BLUSH ON OF ETANOL EXTRACT FROM MIANA PURPLE LEAVES (Coleus scutellarioides L.) AS BLUSHER

Suryanita — 2024-03-02

Anthocyanin is a chemical compound found in purple miana leaves and plays an important role in providing color. Purple miana leaf extract can be used as a natural coloring in blush on cream preparations. The aim of this research is to determine whether purple miana leaf extract (Coleus scutellarioides L) can be formulated in the form of a blush cream dosage form that is physically and chemically stable. The research method used was experimental research by making blush on preparation formulations with concentrations of 7.5%, 10% and 12.5% and evaluating the preparations using physicochemical, irritation tests and hedonic tests. The research results showed that blush on formulations with concentrations of 7.5%, 10% and 12.5% were physically and chemically stable and in the hedonic/preference test the most preferred formulation was the formulation with a concentration of 12.5%. The conclusion of this research is that the ethanol extract of purple miana leaves (Coleus Scutellarioides L) can be formulated in the form of a blush cream dosage form that is physically and chemically stable.