SINGLE ANTIDIABETIC ACTIVITY AND COMBINATION OF AVOCADO LEAVES AND CURCUMA RHIZOME IN VIVO

Abstract

Backgrounds; The prevalence of Diabetes Mellitus is increasing, meanwhile synthetic drugs use raw materials from abroad and undesirable events often occur. Indonesia is known to have thousands of plants with medicinal properties, including avocado leaves and ginger rhizomes which are empirically used by the Dayak people of South Kalimantan in the treatment of Diabetes Mellitus. Some of these empirical uses only use avocado leaves, only ginger rhizomes and some combine avocado leaves and ginger rhizomes and there is no uniform dosage dose; Objectives; Research purposes.Identifying the antidiabetic activity of avocado leaf extract and ginger rhizome alone or in combination. Methods; True experimental,Experimental test with Pre-Posttest Control Group Design. The samples used were 15 male Wistar rats and divided into 5 groups (n = 3), namely the positive group (Metformin 500 mg), the negative group (Na CMC 0.5%) and the treatment group, namely the Combination Formula Group (0 .6 grams of ginger extract and 0.4 grams of avocado), Single Formula Group Temulawak Extract 17.5 mg/kgBB and Single Formula Group Avocado Leaf Extract 175 mg/kgBB given for 14 days. Results; resultThe antidiabetic activity of the ethanol extract of ginger rhizomes was stronger than the ethanol extract of bay leaves, also against Metformin 500 mg. Formula 1 is a combination (0.6 gr of ethanol extract of ginger rhizome (Curcuma xanthorrhiza Roxb.) and 0.4 gr of avocado leaf (Persea americana P. Mill). has stronger antidiabetic activity than single ethanol extract of ginger rhizome or single ethanol extract avocado leaves also Metformin 500 mg. Conclusions; Single or combination of avocado leaf extract and ginger rhizome extract have antidiabetic activity